Preventing Microbial Infections with Natural Phenolic Compounds

The struggle between humans and pathogens has taken is continuing to take countless lives every year. As the misusage of conventional antibiotics increases, complexity associated with resistance mechanisms been evolving into gradually more clever mechanisms, diminishing effectiveness antibiotics. Hence, there a growing interest in discovering novel reliable therapeutics able infection, circumvent defend natural microbiome. In this regard, nature-derived phenolic compounds are gaining considerable attention due their potential safety therapeutic effect. Phenolic comprise numerous widely distributed groups different biological activities attributed mainly structure. Investigations have revealed that from sources exhibit potent antimicrobial activity against various clinically relevant microbial infection sensitize multi-drug strains bactericidal or bacteriostatic This review outlines current knowledge about sources, particular focus on structure-activity relationship actions each class compounds, including simple phenols, acids, coumarin, flavonoids, tannins, stilbenes, lignans, quinones, curcuminoids.